We have developed a suite of paperbased microfluidic devices that enable diagnostic assays to be performed directly at the pointofcare. Dublin, july 14, 2014 prnewswire research and markets has announced the addition of the point of care testing 2014. A paperbased microfluidic biosensor integrating zinc. Recently, paperbased microfluidics has emerged as a multiplexable pointof care platform which might transcend the capabilities of existing assays in resource. Paperplastic hybrid microfluidic device for smartphone. Recent advances in mems technology have provided an opportunity to develop microfluidic devices with enormous potential for portable, point of care, lowcost medical diagnostic tools. A recent national institutes of health report 1 suggests that pointofcare poc testing has the potential to effect a paradigm shift from. However, paper based microfluidics can enable fluid handling and quantitative analysis for potential applications in healthcare, veterinary medicine, environmental. Jun 21, 2012 a large part of the excitement behind microfluidics is in its potential for producing practical devices, but surprisingly few labonachip based technologies have been successfully introduced into the market. Recently, paperbased microfluidics has emerged as a multiplexable pointofcare platform which might transcend the capabilities of existing assays in resourcelimited settings. A paperbased microfluidic biosensor integrating zinc oxide. Handheld flow cytometers will soon be used in disease diagnosis and monitoring. However, paperbased microfluidics can enable fluid handling and quantitative analysis for potential applications in healthcare, veterinary medicine, environmental.
Microfluidics and biosensors for pointofcare diagnostics xuanhong cheng materials science and engineering bioengineering lehigh university november 24, 2014. Pointofcare poc tests are laboratory diagnostic assays performed at or near the. Microfluidic devices for pointofcare diagnostics xuanhong cheng materials science and engineering bioengineering lehigh university december 2, 2016. Jan 23, 2014 paper could lead to lowcost innovative devices and applications is labonachip technology. Microfluidic paperbased analytical devices pads as a promising and. Microfluidic systems enable precise control over tiny volumes of fluid in a compact and lowcost form, thus providing the ideal platform on which to develop point of care diagnostic solutions. Microfluidic paperbased analytical devices pads9 or microfluidics 2. Paper offers a number of attractive characteristics as a platform for sensing in resourcelimited settings. To achieve such devices, new manufacturing methodologies must be developed to allow scalable, lowcost production whilst maintaining good reproducibility and performance. In new work, researchers in korea have, for the first time, used paper as a platform material for actively actuating an electronic microfluidic chip. Paperbased smart microfluidics for education and lowcost. Commercialization of microfluidic pointofcare diagnostic. Prepare patterns for layers of paper, nylon, and adhesive using a graphic design software program.
The aim of this project is to decentralize testing by developing a pointofcare diagnostics platform that can be used in a local clinic. A detector sends realtime sampling data back to the base computer running a labview program, which can be used to relay new commands to the robot and analyze the data transmitted from the robot. Pointofcare, portable microfluidic blood analyzer system. The ideal microfluidic pointofcare device nanowerk spotlight biomarkers are of increasing importance in modern medicine for the purpose of early detection and diagnosis of a disease, for instance cancer.
During this event, you will gain an insight into the latest developments in these exciting fields, we will be covering. Advances in paperbased pointofcare diagnostics sciencedirect. For example, microfluidic devices, coupled with different functional units e. The group is developing labonchip devices for mostly nucleic acid based and antigenantibodybased, onsite detection of pathogens in body fluids and in food and for genotyping. This platform opens new possible applications for paperbased pointof care poc diagnostic devices and enables the possibility of these devices to introduce time control functions without the. Microfluidic chip for pointofcare diagnostics sarah seals, rachel white, florin plesa, heli li product vision to develop a low cost, low power microfluidic device capable of performing cytometry and coagulation tests on whole blood samples in a pointofcare. Research progress of paperbased microfluidic devices. Biomarkers are mostly protein molecules that can be measured in blood, other body fluids, and tissues to assess the presence or state of a. Preparation of paperbased microfluidic device layers. There are increasing successes in developing integrated, microfluidic, disposable diagnostic cards that still require instrumentation. The product that is furthest along is a paperbased pointofcare finger stick transaminase test, used to monitor liver function. May 17, 2011 the ideal microfluidic point of care device nanowerk spotlight biomarkers are of increasing importance in modern medicine for the purpose of early detection and diagnosis of a disease, for instance cancer. Paperbased microfluidic pointofcare diagnostic devices prezi.
Cheap ubiquitous lightweight can be disposed of by incineration, so doesnt produce biohazardous waste. Pads paper is hydrophilic and porous, thus providing a natural platform for fabricating microfluidic channels. Community based care care takes place in the community. Centrifugal microfluidic platform for point of care diagnostics. Point of care testing applications for microfluidic technologies 2014 report by yole developpement 1. Pointofcare diagnostic devices founded in microfluidic technologies will lead the change to personalized medicine, thereby, having a great effect in the diagnosis and treatment of diseases. Microfluidic components and devices, commercialisation of labonachip technology, point of care diagnostics, microfluidics manufacturing technology, biomolecular detection, optics in microfluidics and its applications. Pdf paperbased microfluidic pointofcare diagnostic devices. We gratefully acknowledge the iowa state university foundation and honors program for their support of this research. Active microfluidic chips inkjetprinted on normal paper.
As a service to our customers we are providing this early version of the manuscript. A large part of the excitement behind microfluidics is in its potential for producing practical devices, but surprisingly few labonachip based technologies have been successfully introduced into the market. The pattern may include alignment holes that are not required for a functional paperbased immunoassay, but assist with the reproducible manufacture of threedimensional devices. A pointofcare microfluidic biochip for quantification of.
Paperbased microfluidics combined with printed electronics has the potential to yield exceptionally powerful pointofcare diagnostic devices at extremely low cost. Communitybased care care takes place in the community. Paperbased microfluidic pointofcare diagnostic devices lab on a. A recent national institutes of health report 1 suggests that pointofcare poc testing has the potential to effect a paradigm shift from cura. We expect to see a steady stream of solutions from both small startups and large corporations aimed at addressing, for example, circulating tumor cell detection performed in the doctors office or rapid malaria screening in. Printed electronics integrated with paperbased microfluidics. The current standard for diagnosis, termed as systemic in. Microfluidic devices for bioapplications small 2011, 7, no. Microfluidic systems enable precise control over tiny volumes of fluid in a compact and lowcost form, thus providing the ideal platform on which to develop pointofcare diagnostic solutions. The thirdyear phd students work developing metal doped silica beads for environmental applications has been recognised by the cambridge society for the application of research csar as outstanding research with realworld application. Centrifugal microfluidic platform for pointofcare diagnostics.
Microfluidic modules for pointofcare testing mit tata center. Applications for microfluidic technologies in point of. Can be produced on a mass scale portable 6 what are microfluidic pointofcare diagnostic devices in the year 2004, the world. Carlin, and nastaran hashemi department of mechanical engineering, iowa state university, ames, ia, 50011 introduction the purpose of this research is to create a diagnostic device that keeps the complication level low, the cost low, and efficiency high. Paperbased microfluidic pointofcare diagnostic devices. The goal was to develop lowcost and portable paperbased diagnostic devices to. Microfluidicsbased lowcost medical diagnostic devices. Advantage of microfluidic systems small sample volume small reagent volume. Poc diagnostic devices are not generally intended to replace more sophisticated laboratory tests, but rather provide a means of rapid initial. Introduction as a lightweight analytical tool, paperbased micro. A disposable onchip microvalve and pump for programmable microfluidics. It also has a potential to accomplish complex diagnostic assays, e. Opportunities and challenges for the application of.
Pdf a historical perspective on paper microfluidic based. Paper based microfluidic point of care diagnostic devices. Paper could lead to lowcost innovative devices and applications is labonachip technology. Point of care diagnostics lab on chip micro and nano. A chemically patterned microfluidic paperbased analytical. Here, we present a concise summary of all the recently developed protocols for simple bioassays to complex diagnostics.
Traditionally, and still today, diagnostic tests are usually performed at central laboratories equipped with benchtop analyzers and. The protocol described in this manuscript is specific for paper based immunoassay devices. In underresourced communities, highquality diagnosis can be difficult or impossible to obtain, both in washington state and abroad. Microfluidic modules for pointofcare testing mit tata.
Paperbased microfluidic devices have recently received increasing attention as a potential platform for its low cost, portability and excellent compatibility with biological samples. Fabrication of threedimensional paperbased microfluidic. Labonachip asia microfluidics and point of care diagnostics. Microfluidics and biosensors for pointof care diagnostics. Pointofcare testing poct diagnostic systems are instruments that can rapidly provide in vitro diagnostic results by nontrained personnel at a patient site in the physicians office, the field, the home, an ambulance, or a hospital. Paper based microfluidics combined with printed electronics has the potential to yield exceptionally powerful point of care diagnostic devices at extremely low cost. The future of microfluidic pointofcare diagnostic devices.
The aim of this project is to decentralize testing by developing a point of care diagnostics platform that can be used in a local clinic. Recently, paper based microfluidics has emerged as a multiplexable point of care platform which might transcend the capabilities of existing assays in resourcelimited settings. In these settings, microfluidic systems are poised to bring robust diagnostic tests and a new standard of. This novel, powered fluidic chip known as an active paper open chip apoc allows the full range of fluidic operations by implementing an electric. A 3d diagnostic device based on paper based microfluidics deidre sechi, shayla m.
A small sample of this solution is injected into a microfluidic device that electrophoretically separates the components of the gas. Applications for microfluidic technologies report to their offering. Applications of microfluidic technologies le quartz 75 cours emile zola 69100 lyonvilleurbanne tel. Microfluidic paperbased analytical devices microfluidic paperbased analytical devices. Lowe, journallab on a chip, year20, volume 12, pages 221051. Microfluidic paperbased analytical devices micropads began as a simple idea with an ambitious goal.
Pdf paperbased microfluidic pointofcare diagnostic. A variety of fabrication technologies were employed, including simple photolithography, wax plotting, printing, inkjet etching, plasma etching and so on. While its great that people in developing countries now have increased access to therapies for hiv, tuberculosis and other infectious diseases, the ability to monitor for druginduced liver toxicity is limited. A cassette for the processing of nucleic acids, pcr, and lateral flowbased detection. Integrated paper based microfluidic devices for point of care testing. These formats gained popularity in the consumer markets due to. Towards non and minimally instrumented, microfluidicsbased. Microfluidic cell counting chip daktari diagnostics inc. Overview select biosciences south east asia, the singapore institute of manufacturing technology simtech, and the national university of singapore nus, are pleased to present the third annual labonachip asia conference and exhibition, focusing on microfluidic technologies, pointofcare diagnostics and organonachip. Microfluidic components and devices, commercialisation of labonachip technology, pointofcare diagnostics, microfluidics manufacturing technology, biomolecular detection, optics in microfluidics and its applications.
Microfluidics and biosensors for pointofcare diagnostics xuanhong cheng materials science and engineering bioengineering. News department of chemical engineering and biotechnology. Pads are a new class of pointofcare diagnostic devices that are inexpensive, easy to use, and designed specifically for use in developing countries. Paper based microfluidic systems have emerged as one of the most favorable technologies used in many potential applications such as point of care diagnostics, flexible electronics, energy storage. A centrifugal microfluidic platform for pointofcare diagnostic applications. Microfluidic labonachip technology has a unique characteristic of high surface area to volume ratio resulting in fast analysis time that enables point of care testing poct. We are working in conjunction with achira labs, a bangalore based company that creates and manufactures diagnostic devices in india. The design dispenses with expensive components common in conventional microfluidic devices. In vitro diagnostic ivd devices will find their way far down the care settings continuum for all indication spaces. Paper based microfluidic point of care diagnostic devices free download as pdf file. Paperbased microfluidic pointofcare diagnostic devices for. A 3d diagnostic device based on paperbased microfluidics deidre sechi, shayla m.
Dipsticks and lateral flow are the established assay formats for pointofcare testing. Microfluidic technologies have been widely employed in developing poc diagnostics to address global health issues because of their evident advantages hawkins and weigl, 2010. Biomarkers are mostly protein molecules that can be measured in blood, other body fluids, and tissues to assess the presence or state of a disease. This is a pdf file of an unedited manuscript that has been accepted for publication. To test the devices ability to be used for disease detection protein tp0100 and. A 3d diagnostic device based on paperbased microfluidics 1. Currently, in its early development stages, paperbased microfluidics is considered a lowcost, lightweight, and disposable technology.
The goal was to develop lowcost and portable paperbased diagnostic devices to improve healthcare in developing countries. Recent advances in mems technology have provided an opportunity to develop microfluidic devices with enormous potential for portable, pointofcare, lowcost medical diagnostic tools. Apr 26, 2017 a chemically patterned microfluidic paperbased analytical device cpad is developed to create fluidic networks by forming hydrophobic barriers using chemical vapor deposition cvd of. Dipstick and lateralflow formats have dominated rapid diagnostics over the last three decades. Point of care testing applications for microfluidic. A centrifugal microfluidic platform for point of care diagnostic applications. This platform opens new possible applications for paper based point of care poc diagnostic devices and enables the possibility of these devices to introduce time control functions without the. Paper based microfluidic point of care diagnostic devices received 6th february 20, accepted 18th march 20 doi. Paperbased diagnostic microfluidic devices medgadget.
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